How your Menstrual Cycle effects your Immune system

 



Your immune system is the basis of your health. Most of the time, it works for you by fighting off infection and helping fix injury. Although sometimes your immune system works against you, causing or influencing chronic diseases like allergies and arthritis.

Sex hormones, such as estrogen, progesterone, and testosterone, seem to affect the immune system and its function. There is evidence to suggest that premenopausal people’s bodies react differently to illnesses and infections over the course of their menstrual cycle due, at least in part, to fluctuations in sex hormones.

Understanding how your immune system functions can help you appreciate and anticipate your healthy days and less-healthy days.

Your immune system can be roughly broken into three categories:

  1. Innate immunity: This includes secretion of mucus and some types of immune cells.
  2. Inflammation: When your body is exposed to foreign substances, such as bacteria, or are injured, your immune system will stage an inflammatory response. Acute inflammation helps protect tissue and increases the number of immune cells at an infection or wound site, while chronic inflammation can lead to chronic diseases.
  3. Acquired immunity: We develop acquired immunity when exposed to bacteria, viruses, and other substances. Acquired immunity includes B and T lymphocytes, and antibodies that have developed in response to infection and vaccination (1-3).

The first part of your cycle: the follicular phase

During the follicular phase of the menstrual cycle (i.e. the first part of the cycle, from the first day of the period until ovulation), people tend to have higher levels of antibodies in their body and have an increased inflammatory response (1, 4). These changes makes people less susceptible to infection during this phase of their cycle (1, 4).

This increased immune response is thought to be partially triggered by rising estrogen levels that occur between menstruation until just before ovulation (1, 5, 6). Estrogen interacts with immune cells by attaching to receptors on the outside of the cells, and by interacting with cell processes occuring in the nucleus and cytoplasm (4, 7). During the follicular phase, this interaction increases inflammation, though estrogen doesn’t always necessarily have that effect (1).

Higher estrogen does not necessarily mean better health, as the higher inflammatory response caused by estrogen can lead to a worsening of chronic disease (1, 4, 7). Also, prolonged exposure to endogenous (i.e. from the body) estrogen is associated with the development of certain cancers, such as breast cancer (8).


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